FDA label ladder

Tirzepatide FDA label ladder to 15 mg: published ladder and modeled levels

Updated by the GLP Ladder Editorial Team. Editorial policy.

Short answer

Tirzepatide FDA label ladder to 15 mg: 2.5/5/7.5/10/12.5/15 mg weekly, 4 weeks per step (DailyMed, Aug 28, 2026). The final 15 mg step begins in week 21. With t½ 5 days and R = 1.6101, the modeled amount peaks at 21.46 mg-eq. As published, not a recommendation; as of Oct 19, 2026.

Weeks per step
4 6 steps
Final step
15 mg from week 21
Modeled peak
21.46 mg-eq
Accumulation R
1.6101 t½ 5 d
Tirzepatide FDA label ladder to 15 mg: steps and modeled amountWeekly doses 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg; modeled amount peaks at 21.46 mg-equivalents.stable window06.2512.518.7525mg-eq048121620242832weeks from start2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg
  • Weekly dose (published steps)
  • Modeled amount (mg-eq)
  • Stable window
Steps start on a Monday (Jan 5, 2026) for illustration. Curve: modeled relative amount, not plasma concentration. Open in the Tirzepatide plotter to change dates or doses.
FDA label ladder to 15 mg: weeks, weekly dose and dates from a Jan 5, 2026 start (DailyMed, Aug 28, 2026)
WeeksWeekly doseFirst week starts
1–4 2.5 mg Jan 5, 2026
5–8 5 mg Feb 2, 2026
9–12 7.5 mg Mar 2, 2026
13–16 10 mg Mar 30, 2026
17–20 12.5 mg Apr 27, 2026
21 onward 15 mg May 25, 2026

Weekly modeled amounts

Download CSV

32 weeks. Highlighted rows start a new dose step. Model details: model card.

Tirzepatide FDA label ladder to 15 mg: weekly peak, trough and average (mg-equivalents)
WeekStartsDose mgPeakTroughAverage
1Jan 5, 20262.52.17601.506
2Jan 12, 20262.53.0430.9892.171
3Jan 19, 20262.53.3751.3632.422
4Jan 26, 20262.53.5011.5052.518
5Feb 2, 202655.7181.5594.06
6Feb 9, 202656.6092.5684.738
7Feb 16, 202656.9482.9514.995
8Feb 23, 202657.0773.0955.093
9Mar 2, 20267.59.2923.156.636
10Mar 9, 20267.510.1874.167.314
11Mar 16, 20267.510.5254.5427.571
12Mar 23, 20267.510.6544.6877.669
13Mar 30, 20261012.874.7429.212
14Apr 6, 20261013.7645.7529.89
15Apr 13, 20261014.1036.13410.147
16Apr 20, 20261014.2326.27910.245
17Apr 27, 202612.516.4476.33411.788
18May 4, 202612.517.3417.34412.466
19May 11, 202612.517.687.72612.723
20May 18, 202612.517.817.87112.821
21May 25, 20261520.0257.92614.364
22Jun 1, 20261520.9198.93615.042
23Jun 8, 20261521.2589.31815.3
24Jun 15, 20261521.3879.46315.397
25Jun 22, 20261521.4369.51815.434
26Jun 29, 20261521.4559.53915.448
27Jul 6, 20261521.4629.54715.453
28Jul 13, 20261521.4649.5515.455
29Jul 20, 2026—10.0033.8126.42
30Jul 27, 2026—3.791.4452.433
31Aug 3, 2026—1.4360.5470.922
32Aug 10, 2026—0.5440.2070.349

The label sets a minimum of 4 weeks per step; maintenance can be 5, 10 or 15 mg (Zepbound). The plot holds each step exactly 4 weeks.

Sources

  1. ZEPBOUND (tirzepatide) injection, for subcutaneous use - Full Prescribing Information, Medication Guide and Instructions for Use (DailyMed SPL set ID 487cd7e7-434c-4925-99fa-aa80b1cc776b, version 40). U.S. National Library of Medicine (DailyMed) / Eli Lilly and Company, Aug 28, 2026. Accessed Oct 19, 2026.
  2. MOUNJARO (tirzepatide) injection, for subcutaneous use - Full Prescribing Information, Medication Guide and Instructions for Use (DailyMed SPL set ID d2d7da5d-ad07-4228-955f-cf7e355c8cc0, version 40). U.S. National Library of Medicine (DailyMed) / Eli Lilly and Company, Aug 27, 2026. Accessed Oct 19, 2026.

Tools

Guides and data