Published Dose Ladders: Modeled Level Datasets

Retatrutide

Phase 3 12 mg arm Trial
2 → 4 → 6 → 9 → 12 mg, 4 weeks per step
Phase 3 9 mg arm Trial
2 → 4 → 6 → 9 mg, 4 weeks per step
Phase 3 4 mg arm Trial
2 → 4 mg, 4 weeks per step
Phase 2 12 mg arm Trial
2 → 4 → 8 → 12 mg, 4 weeks per step
Phase 2 8 mg arm (2 mg start) Trial
2 → 4 → 8 mg, 4 weeks per step
Phase 2 8 mg arm (4 mg start) Trial
4 → 8 mg, 4 weeks per step

Tirzepatide

FDA label ladder to 15 mg FDA label
2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg, 4 weeks per step
FDA label ladder to 5 mg FDA label
2.5 → 5 mg, 4 weeks per step

Semaglutide

Wegovy label ladder to 2.4 mg FDA label
0.25 → 0.5 → 1 → 1.7 → 2.4 mg, 4 weeks per step
Ozempic label ladder to 2 mg FDA label
0.25 → 0.5 → 1 → 2 mg, 4 weeks per step