What is the tirzepatide dose schedule on the label?

The Zepbound and Mounjaro labels start at 2.5 mg once weekly for 4 weeks, then 5 mg, with increases in 2.5 mg steps after at least 4 weeks on the current dose, to a maximum of 15 mg. Zepbound lists 5, 10 or 15 mg maintenance for weight reduction.

Can the weeks per step be changed?

Yes, the calculator accepts any number of weeks per step. The published label uses at least 4 weeks per step; labels allow a prescriber to hold a step longer.

Does the table show doses or dates first?

Each row is one week: week number, the Monday-to-Sunday dates from your start date, and the weekly dose. Step changes are highlighted, and the first date of each new step is listed separately.

Where can I see how a ladder changes modeled levels?

Open the same ladder in the Tirzepatide plotter: it draws each step above the modeled amount so you can see the build-up after each increase.

Is tirzepatide FDA approved?

Yes. FDA approved as Mounjaro (type 2 diabetes) and Zepbound (weight management, obstructive sleep apnea). Numbers on this page quote the FDA prescribing information; your prescriber sets your dose.

Tirzepatide Titration Schedule Calculator

Short answer

Week of step k = 1 + weeks per step × (k − 1). From a Jan 5, 2026 start, 5 mg begins week 5 (Feb 2) and, stepping every 4 weeks, 15 mg begins week 21 (May 25). It shows the FDA label ladder, not a recommendation; your prescriber sets your steps. Dates as of Oct 19, 2026.

6 steps.

2.5 mg from week 1 (Jan 5, 2026)
5 mg from week 5 (Feb 2, 2026)
7.5 mg from week 9 (Mar 2, 2026)
10 mg from week 13 (Mar 30, 2026)
12.5 mg from week 17 (Apr 27, 2026)
15 mg from week 21 (May 25, 2026)

Each tread is one step; width is weeks held, height is the weekly dose.

FDA label ladder to 15 mg: week-by-week from Jan 5, 2026
Week	Dates	Weekly dose
1	Jan 5, 2026 – Jan 11, 2026	2.5 mg
2	Jan 12, 2026 – Jan 18, 2026	2.5 mg
3	Jan 19, 2026 – Jan 25, 2026	2.5 mg
4	Jan 26, 2026 – Feb 1, 2026	2.5 mg
5	Feb 2, 2026 – Feb 8, 2026	5 mg (step up)
6	Feb 9, 2026 – Feb 15, 2026	5 mg
7	Feb 16, 2026 – Feb 22, 2026	5 mg
8	Feb 23, 2026 – Mar 1, 2026	5 mg
9	Mar 2, 2026 – Mar 8, 2026	7.5 mg (step up)
10	Mar 9, 2026 – Mar 15, 2026	7.5 mg
11	Mar 16, 2026 – Mar 22, 2026	7.5 mg
12	Mar 23, 2026 – Mar 29, 2026	7.5 mg
13	Mar 30, 2026 – Apr 5, 2026	10 mg (step up)
14	Apr 6, 2026 – Apr 12, 2026	10 mg
15	Apr 13, 2026 – Apr 19, 2026	10 mg
16	Apr 20, 2026 – Apr 26, 2026	10 mg
17	Apr 27, 2026 – May 3, 2026	12.5 mg (step up)
18	May 4, 2026 – May 10, 2026	12.5 mg
19	May 11, 2026 – May 17, 2026	12.5 mg
20	May 18, 2026 – May 24, 2026	12.5 mg
21	May 25, 2026 – May 31, 2026	15 mg (step up)
22	Jun 1, 2026 – Jun 7, 2026	15 mg
23	Jun 8, 2026 – Jun 14, 2026	15 mg
24	Jun 15, 2026 – Jun 21, 2026	15 mg

Math, parameters and sources: model card.

Where the ladders come from

Tirzepatide ladders in this calculator
Ladder	Steps (mg, weekly)	Source
FDA label ladder to 15 mg	2.5 → 5 → 7.5 → 10 → 12.5 → 15	DailyMed, Aug 28, 2026
FDA label ladder to 5 mg	2.5 → 5	DailyMed, Aug 28, 2026

FDA labels set a minimum of 4 weeks per step; a prescriber may hold a step longer. The table assumes exactly 4 weeks so the dates are a best case, not a plan.

Frequently asked questions

What is the tirzepatide dose schedule on the label?: The Zepbound and Mounjaro labels start at 2.5 mg once weekly for 4 weeks, then 5 mg, with increases in 2.5 mg steps after at least 4 weeks on the current dose, to a maximum of 15 mg. Zepbound lists 5, 10 or 15 mg maintenance for weight reduction.
Can the weeks per step be changed?: Yes, the calculator accepts any number of weeks per step. The published label uses at least 4 weeks per step; labels allow a prescriber to hold a step longer.
Does the table show doses or dates first?: Each row is one week: week number, the Monday-to-Sunday dates from your start date, and the weekly dose. Step changes are highlighted, and the first date of each new step is listed separately.
Where can I see how a ladder changes modeled levels?: Open the same ladder in the Tirzepatide plotter: it draws each step above the modeled amount so you can see the build-up after each increase.
Is tirzepatide FDA approved?: Yes. FDA approved as Mounjaro (type 2 diabetes) and Zepbound (weight management, obstructive sleep apnea). Numbers on this page quote the FDA prescribing information; your prescriber sets your dose.

Sources

ZEPBOUND (tirzepatide) injection, for subcutaneous use - Full Prescribing Information, Medication Guide and Instructions for Use (DailyMed SPL set ID 487cd7e7-434c-4925-99fa-aa80b1cc776b, version 40). U.S. National Library of Medicine (DailyMed) / Eli Lilly and Company, Aug 28, 2026. Accessed Oct 19, 2026.
MOUNJARO (tirzepatide) injection, for subcutaneous use - Full Prescribing Information, Medication Guide and Instructions for Use (DailyMed SPL set ID d2d7da5d-ad07-4228-955f-cf7e355c8cc0, version 40). U.S. National Library of Medicine (DailyMed) / Eli Lilly and Company, Aug 27, 2026. Accessed Oct 19, 2026.

Printed from GLP Ladder. To recreate this result, open https://glpladder.com/tools/tirzepatide-titration/

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