FDA label ladder

Tirzepatide FDA label ladder to 5 mg: published ladder and modeled levels

Updated by the GLP Ladder Editorial Team. Editorial policy.

Short answer

Tirzepatide FDA label ladder to 5 mg: 2.5/5 mg weekly, 4 weeks per step (DailyMed, Aug 28, 2026). The final 5 mg step begins in week 5. With t½ 5 days and R = 1.6101, the modeled amount peaks at 7.16 mg-eq. As published, not a recommendation; as of Oct 19, 2026.

Weeks per step
4 2 steps
Final step
5 mg from week 5
Modeled peak
7.16 mg-eq
Accumulation R
1.6101 t½ 5 d
Tirzepatide FDA label ladder to 5 mg: steps and modeled amountWeekly doses 2.5 mg, 5 mg; modeled amount peaks at 7.16 mg-equivalents.stable window02.557.510mg-eq024681012141618202224weeks from start2.5 mg5 mg
  • Weekly dose (published steps)
  • Modeled amount (mg-eq)
  • Stable window
Steps start on a Monday (Jan 5, 2026) for illustration. Curve: modeled relative amount, not plasma concentration. Open in the Tirzepatide plotter to change dates or doses.
FDA label ladder to 5 mg: weeks, weekly dose and dates from a Jan 5, 2026 start (DailyMed, Aug 28, 2026)
WeeksWeekly doseFirst week starts
1–4 2.5 mg Jan 5, 2026
5 onward 5 mg Feb 2, 2026

Weekly modeled amounts

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24 weeks. Highlighted rows start a new dose step. Model details: model card.

Tirzepatide FDA label ladder to 5 mg: weekly peak, trough and average (mg-equivalents)
WeekStartsDose mgPeakTroughAverage
1Jan 5, 20262.52.17601.506
2Jan 12, 20262.53.0430.9892.171
3Jan 19, 20262.53.3751.3632.422
4Jan 26, 20262.53.5011.5052.518
5Feb 2, 202655.7181.5594.06
6Feb 9, 202656.6092.5684.738
7Feb 16, 202656.9482.9514.995
8Feb 23, 202657.0773.0955.093
9Mar 2, 202657.1263.155.13
10Mar 9, 202657.1443.1715.144
11Mar 16, 202657.1513.1795.149
12Mar 23, 202657.1543.1825.151
13Mar 30, 202657.1553.1835.152
14Apr 6, 202657.1553.1845.152
15Apr 13, 202657.1553.1845.152
16Apr 20, 202657.1553.1845.152
17Apr 27, 202657.1553.1845.152
18May 4, 202657.1553.1845.152
19May 11, 202657.1553.1845.152
20May 18, 202657.1553.1845.152
21May 25, 2026—3.3341.2712.14
22Jun 1, 2026—1.2640.4820.811
23Jun 8, 2026—0.4790.1820.307
24Jun 15, 2026—0.1810.0690.116

Sources

  1. ZEPBOUND (tirzepatide) injection, for subcutaneous use - Full Prescribing Information, Medication Guide and Instructions for Use (DailyMed SPL set ID 487cd7e7-434c-4925-99fa-aa80b1cc776b, version 40). U.S. National Library of Medicine (DailyMed) / Eli Lilly and Company, Aug 28, 2026. Accessed Oct 19, 2026.

Tools

Guides and data