FDA label ladder

Semaglutide Ozempic label ladder to 2 mg: published ladder and modeled levels

Updated by the GLP Ladder Editorial Team. Editorial policy.

Short answer

Semaglutide Ozempic label ladder to 2 mg: 0.25/0.5/1/2 mg weekly, 4 weeks per step (Novo Nordisk, Jun 1, 2026). The final 2 mg step begins in week 13. With t½ 7 days and R = 2, the modeled amount peaks at 3.56 mg-eq. As published, not a recommendation; as of Oct 19, 2026.

Weeks per step
4 4 steps
Final step
2 mg from week 13
Modeled peak
3.56 mg-eq
Accumulation R
2 t½ 7 d
Semaglutide Ozempic label ladder to 2 mg: steps and modeled amountWeekly doses 0.25 mg, 0.5 mg, 1 mg, 2 mg; modeled amount peaks at 3.56 mg-equivalents.stable window01.252.53.755mg-eq0481216202428weeks from start0.25 mg0.5 mg1 mg2 mg
  • Weekly dose (published steps)
  • Modeled amount (mg-eq)
  • Stable window
Steps start on a Monday (Jan 5, 2026) for illustration. Curve: modeled relative amount, not plasma concentration. Open in the Semaglutide plotter to change dates or doses.
Ozempic label ladder to 2 mg: weeks, weekly dose and dates from a Jan 5, 2026 start (Novo Nordisk, Jun 1, 2026)
WeeksWeekly doseFirst week starts
1–4 0.25 mg Jan 5, 2026
5–8 0.5 mg Feb 2, 2026
9–12 1 mg Mar 2, 2026
13 onward 2 mg Mar 30, 2026

Weekly modeled amounts

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28 weeks. Highlighted rows start a new dose step. Model details: model card.

Semaglutide Ozempic label ladder to 2 mg: weekly peak, trough and average (mg-equivalents)
WeekStartsDose mgPeakTroughAverage
1Jan 5, 20260.250.21500.165
2Jan 12, 20260.250.330.1310.263
3Jan 19, 20260.250.3870.1970.312
4Jan 26, 20260.250.4160.2290.336
5Feb 2, 20260.50.6450.2460.513
6Feb 9, 20260.50.7680.3850.617
7Feb 16, 20260.50.8290.4550.669
8Feb 23, 20260.50.860.4890.695
9Mar 2, 202611.3030.5071.038
10Mar 9, 202611.5420.7771.24
11Mar 16, 202611.6620.9131.342
12Mar 23, 202611.7220.9811.392
13Mar 30, 202622.6071.0142.077
14Apr 6, 202623.0841.5552.481
15Apr 13, 202623.3241.8262.683
16Apr 20, 202623.4451.9612.784
17Apr 27, 202623.5052.0292.835
18May 4, 202623.5352.0632.86
19May 11, 202623.552.082.873
20May 18, 202623.5582.0882.879
21May 25, 202623.5612.0922.882
22Jun 1, 202623.5632.0942.884
23Jun 8, 202623.5642.0952.885
24Jun 15, 202623.5652.0962.885
25Jun 22, 2026—2.1671.0881.566
26Jun 29, 2026—1.0830.5440.783
27Jul 6, 2026—0.5420.2720.392
28Jul 13, 2026—0.2710.1360.196

Sources

  1. OZEMPIC (semaglutide) injection, for subcutaneous use - Full Prescribing Information (SPL). Novo Nordisk / National Library of Medicine DailyMed, Jun 1, 2026. Accessed Oct 19, 2026.
  2. WEGOVY (semaglutide) injection, for subcutaneous use; WEGOVY (semaglutide) tablets, for oral use - Full Prescribing Information (SPL, Revised 6/2026). Novo Nordisk / National Library of Medicine DailyMed, Jun 18, 2026. Accessed Oct 19, 2026.

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